Kane's performance in Spurs' 1-1 home draw against Manchester United on Friday prompted former Arsenal star Paul Merson to cast doubt over the britain captain's suitability in Mourinho's system.
Responding at a press conference before Tuesday's home Premier League match with West Ham, the previous Manchester United, Real Madrid, Chelsea and Inter boss stressed he respects Merson.
But Mourinho felt the comments had prompted unfair analysis over Kane's future at Spurs.
He embarked on a four-minute answer listing forwards who had succeeded under his management, including Cristiano Ronaldo and Zlatan Ibrahimovic, amid statistics.
Kane had scored seven goals in 10 matches before suffering a significant hamstring injury on January 1, with the United game, during which he played the complete 90 minutes, marking his return to action.
"I feel a touch strange about some analysis and a few comments," said Mourinho. "The beginning of some comments and analysis started from Paul.
"I need to say I respect people tons like him and since I respect him tons , i would like to be nice in my answer. I attempt to be nice and that i try just to mention something where people can think a touch a touch .
"First of all, Harry played his first game for 6 months and if you watch the sport and you analyse the sport , compare Harry Kane with Anthony Martial.
"Was it a game of the many chances? Was it a game where the 2 strikers had tons of chances? does one give credit to my defence for Martial's game?
"Do you give credit to United's defence and for the occasions we created or we didn't create? i feel you've got to seem at it during a balanced approach.
"In our case, Harry doesn't play a game for 6 months. Phenomenal [that he played 90 minutes].
"The record of goals that Harry has with me is straightforward for you. you only look, attend your data and it's easy to ascertain what percentage matches Harry played with me before his injury and the way many goals he scored."
Uninterrupted, Mourinho's impassioned defence continued as he added: "I can say that I had a couple of strikers that played on behalf of me and that they aren't bad.
"I had one guy called [Didier] Drogba. He played on behalf of me [over] four seasons. He scored 186 goals which provides a mean of 46 goals per season.
"I had one guy that's not also bad - he [Ronaldo] plays for Juventus now. He played on behalf of me [during] three seasons. He scored 168 goals, which provides a mean of 56 goals per season.
"I had another guy who isn't also bad called Karim Benzema. He played on behalf of me [during] three seasons.
"He wasn't always starting because he was quite young at that point . But he scored on behalf of me 78 goals in three season which provides a 26-goal average per season.
"I had another one called [Diego] Milito. He played one season on behalf of me [and] he scored 30 goals. He won three titles and in fact the typical is 30 [per season].
"I had another guy that played on behalf of me [over] one and a half seasons - I say one and half because within the spouse he had an enormous injury. A tall guy called Zlatan [Ibrahimovic].
"He played one and a half seasons. He scored 58 goals which provides a 29-goal average per season.
"So, dear Paul, I even have many respect for you. [But] i feel Harry Kane has no problems in the least to attain goals in my teams.
"Especially when he's fit, fresh, when he has routines of playing. So, that's my message to somebody that I even have many respect for."
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